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This variation in treatment effect is suspected to be due to differences in medications, differences in methodology for lean mass assessment, and different lifestyle interventions prescribed in combination with pharmacological therapies [71]

The two approaches may be complementary rather than mutually exclusive

The ventral pallidum (VP) receives GABAergic inputs from the nucleus accumbens and projects to the mediodorsal thalamic nucleus and prefrontal cortex, forming the cortex-striatum-cortex loop, which regulates motivated behavior and reward evaluation (23)